Always close to the current composition, many composers have dedicated their works to him, as Joaquín Rodrigo, Federico Moreno Torroba, Francisoc de Madina, Lorenzo Palomo, Michael Zearrot, Paul Chihara, Ernesto Cordero or Loris Tjeknavorian. He has worked under the baton of prestigious conductors like Eugene Ormandy, Arthur Fiedler, Lawrence Foster, Leonard Slatkin, Philippe Entremont, Christoph Eschenbach and, specially, with Sir Neville Marriner and Rafael Frühbeck de Burgos, as well as several renowned Spanish conductors.

Along with his father and brothers, he formed The Romeros quartet, unique ensemble. He has performed by himself and with his family at the White House, the Vatican for Pope John Paul II and for several European monarchs. He has given master classes at the summer Academy in Salzburg and in the Schleswig- Holstein Festival.
His wide discography includes more than 20 recordings with the Academy of St. Martin- in-the-Fields and Sir Neville Marriner. He has recorded for Decca, Naxos, Sony, CPA, Hollywood Records, and specially for Philips.

Presently he gives master classes at the Thornton School of Music at the University of Southern California. Pepe Romero holds an honorary doctorate in music from the University of  Victoria, British Columbia.